Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage.

نویسندگان

  • Sherri Tran
  • Shangbin Chen
  • Ran R Liu
  • Yicheng Xie
  • Timothy H Murphy
چکیده

We studied the acute (up to 2 hours after reperfusion) effects of localized cortical hypothermia on ischemia-induced dendritic structural damage. Moderate (31°C) and deep (22°C) hypothermia delays, but does not block the onset of dendritic blebbing or spine loss during global ischemia in mouse in vivo. Hypothermic treatment promoted more consistent recovery of dendritic structure and spines during reperfusion. These results suggest that those using therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but hypothermia may interact with mechanisms that control the onset of damage and recovery during reperfusion.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Delayed combination therapy of local brain hypothermia and decompressive craniectomy on acute stroke outcome in rat

Objective(s):Hypothermia and decompressive craniectomy (DC) have been shown to be neuroprotective. This study was designed to evaluate neuroprotective effects of delayed singular or combination of DC and local hypothermia on stroke. Materials and Methods: Cerebral ischemia was induced in 48 Wistar rats assigned to 4 groups: control, decompressive craniectomy (DC), local hypothermia (LH), combin...

متن کامل

Hypothermia and stroke: the pathophysiological background.

Hypothermia to mitigate ischemic brain tissue damage has a history of about six decades. Both in clinical and experimental studies of hypothermia, two principal arbitrary patterns of core temperature lowering have been defined: mild (32-35 degrees C) and moderate hypothermia (30-33 degrees C). The neuroprotective effectiveness of postischemic hypothermia is typically viewed with skepticism beca...

متن کامل

Dendritic Spines and Pre-Synaptic Boutons Are Stable Despite Local Deep Hypothermic Challenge and Re-Warming In Vivo

BACKGROUND AND PURPOSE Deep hypothermia to 20°C is used clinically for major pediatric and adult surgical procedures. In particular, it is used in the "standstill operation" where blood flow is stopped for up to 30 min. Patients recovering from these procedures can exhibit neurological deficits. Such deficits could arise from changes to dendritic spines and plasticity-induced changes in network...

متن کامل

Evaluation the protective effect of aminoguanidine on cortex and striatum damage in acute phase of focal cerebral ischemia in rat

Introduction: Several studies have indicated that late treatment of aminoguanidine (AG) reduces cerebral ischemic injuries in animal models. However, the effects of early treatment of AG on cerebral ischemic damage are not well understood. This study was designed to evaluate effect of early treatment of AG on cortex and striatum injuries as well as neurological dysfunctions in transient mode...

متن کامل

Effect of Endothelin-A Receptor Blockade on the Early Phase of Ischemia/Reperfusion-Induced Acute Renal Failure in Anesthetized Rats

Background: Previous studies have shown increases in endothelin (ET) concentration of plasma and renal tissues in acute renal failure (ARF).  ET has a potent vasoconstrictor effect, through binding with its ETA receptors, and may play some roles in renal hemodynamic dysfunction in ARF.Objective: To examine the beneficial effect of a selective ETA-receptor antagonist on renal dysfunction and tis...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

دوره 32 3  شماره 

صفحات  -

تاریخ انتشار 2012